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Implementing Post-Genomic Personalized Medicine: The Rise of Glycan Biomarkers

An in-depth look at the science of glycobiology and glycan diagnostics, and their promises in personalized medicine in the current post-genomic era, will be featured in a special issue of the OMICS: A Journal of Integrative Biology.

This particular edition was co-edited by Wei Wang, MD, Ph. D., Edith Cowan University (Joondalup, Australia) and Capital Medical University (Beijing, China) and Vural Ă–zdemir, MD, Ph. D., Editor-in -Chief from OMICS: A Journal of Integrative Biology. Dr. Wang and a team of researchers from Australia, China and Croatia contributed an article entitled "Diabetes Mellitus Type 2 Is Associated with Immunoglobulin GN-Glycome by Putative Proinflammatory Mechanisms in an Australian Population.") The team analyzed the N- glycan patterns of immunoglobulin G (IgG) in persons with type 2 diabetes (T2D) and novel associations between the IgG-N-glycome, T2D and clinical risk factors associated with proinflammatory mechanisms. These IgG-N-glycomic changes offer promise as future biomarkers for T2D diagnosis or monitoring of the progression of cardiovascular disease or kidney failure.

A review article by Tanja Kunej, Ph. D. of the University of Ljubljana (Domzale, Slovenia) entitled "The Rise of Represented and Personalized Glycomedicine Systems: Why and How to Integrate Glycomics with Multiomics Science?" Kunej suggests that for glycomics to make a larger, systems, scale contribution to biology and medicine it will take the transition from a single omics science to multiomics technology platforms. The article shows examples of glycomics in conjunction with other omics areas, including genomics, transcriptomics, proteomics, metabolomics, and epigenomics, presents and discusses current knowledge gaps and suggests future research directions.

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