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At the end of 2001, through research, I discovered many studies that evaluated the intake of enzymes as very positive for lymphedema and a positive side effect that our immune system is significantly strengthened. These studies show that enzymes mainly proteolytic, i.e. protein-splitting enzymes, considerably reduce edema / lymphedema. The studies are quite positive.

We know that edema is mostly high in protein. The proteolytic and fibrinolytic properties of enzymes lead to a breakdown of lymphatic occlusions and help in the reconstruction of lymphatic passages, which can then dissolve the deposited proteins. Enzymes reduce inflammation and help or prevent our tissue from hardening in the affected regions. The important thing is the composition of the enzymes, as similar as possible to the body's components, not all of them achieve the same effect on lymphedema, I take Karazym.


I am very excited to share this scientific article with you. It is a great honor for me to have Dr. Inderst for my blog and everyone who needs help has made this available. Many thanks again at this point!

I'm very happy and proud to be able to present a very interesting article about enzymes and how they can help to cope with lymphedema. I am the best example, I've been taking enzymes, vitamins, high dosage D3, selenium and antioxidants for years and due to that and other methods that I am using I can lead an almost normal life. I'm very proud that Dr. Inderst has taken the time to write about this especially for my blog and my international readers. If you have any questions let me know and I'll be happy to help.


C.chronic L.ymphödeme (cLÖ) - origin and

Naturopathic therapy, especially taking into account regulatory enzyme therapy

Dr. med. Rudolf Inderst

MEF (Medical Enzyme Research Society) eV, Grassau


Lymphedema is by no means uncommon: in Germany around 4.5 million people are affected by this disease unit, and worldwide 60 to 120 million. In view of the large number of patients, it is surprising that z. For example, in contrast to research approaches in rheumatoid arthritis (1.2 million people affected in Germany), only a few specialist medical congresses are held and / or there are only a few current scientific treatises. Medical students also learn a lot about arteries and veins, but far too little about lymphatic vessels. The white fluid-carrying vessels were already known in antiquity, their crucial importance in humoral medicine was well understood, but in modern medicine, lymphatic vessels are neglected. There is no separate additional designation in the further training regulations for doctors and specialist clinics for specific treatment are also sparse in Germany. Unfortunately, these clinics are mostly private facilities and are therefore difficult to access for those affected for reasons of cost.

Root cause research

The causes of csLÖ in Europe are chronic inflammation, tumor infiltration into lymph vessels, postoperative lymphadenectomy and changes that occur after tumors have been irradiated. Breast cancer is the most common cause here.

Not to be forgotten is the post-thrombotic syndrome - after repeated phlebitis or thrombosis - which results in chronic venous insufficiency with secondary lymphedema.

An intensive study of the worldwide literature reveals important new insights into the individual pathological development of lymphedema.

The basis of the knowledge is that LÖ develops due to increased pressure within the lymph vessels and that - in contrast to cardiac edema - it is a protein-rich edema. This results in reactive steps in the surrounding tissue or the lymph vessels. The increasing sclerosis / fibrosis of the tissue can be seen with the naked eye and especially with a light microscope, especially in the higher stages (stages 2 + 3). As a result, the subcutaneous fat pad is narrowed and the vulnerability in these areas increases: Possible entry points for pathogenic germs. The recurring inflammatory reactions (erysipelas), which have been known for many years, are the typical consequence.

Biochemically, so-called matrix metalloproteases (MMP 1,3,9) can increasingly be detected in the affected tissue, which initiate an increased breakdown of specific connective tissue structures. The concentration of the opponents (TIMPS) is reduced, as has already been observed in chronic non-healing wounds. At the same time, phagocytes migrating into the surrounding tissue and preformed TGF beta from the tissue are released in unphysiologically high concentrations and thus the fibrosis of the tissue is set in motion or maintained. Some researchers have also shown in animal studies that there are also abnormally high levels of IL 6 and thus one in connection with increased TGF induce typical chronic inflammation. Interestingly, the highly active macrophages / phagocytes that migrate to the affected area have significantly increased concentrations of defensins, including lysozyme: The same applies to the keratinocytes in this area: constitutionally, lysozyme is already present and after trauma, alpha- and beta- Defensine. This means that the organism wants to counteract possible infections with the help of defensins!


LÖ are usually divided into 3 different degrees of severity, whereby it is assumed that a (defect) healing is possible up to stage 2. The pre- or latency stage (stage 0) can last for life or move to stage I if adequate treatment is not carried out. The still soft edema (typical dents) can be influenced well by targeted elevation of the leg. However, fibrosis of the tissue had already set in at this point. If the disease progresses, the swelling cannot be removed even by elevating the leg. The doughy swelling develops into the III. Stage typical hard swelling or elephantiasis. In addition, irreversible skin symptoms such as discoloration occur. Lymphologically trained doctors should decide together with surgeons whether surgical measures are still useful.

Therapy options:

The first naturopathic measure should be:

Supply of highly active proteases such as bromelain, lysozyme and trypsin and parallel administration of antioxidants (e.g. innovazym, Fa Innova Vital). In this way, the excessive inflammatory processes are sensibly regulated down!

For example, selenium and phytochemicals can be added, which are then available as intra- and extracellular antioxidants, such as zinc, vitamins C and E and lysozyme!

Such changes in the lymphatic vessel area measurably lead to increased oxidative stress and the unusual pressure also lowers the local oxygen supply. Even in the more recent medical science one had rightly spoken of a “swamping” of the tissue, in biological medicine terms like “slagging and hyperacidity” are used.

It has been known for a long time that the body's own anti-oxidative protective systems (glutathione, etc.) are increasingly exhausted in the case of chronic inflammation and thus the formation of radicals increases. The consequence is, among other things, an increased permeability of vessels.

In this context, attention should be drawn to the additive effect of vitamin D3 (D-Mulsin). Current immunological research shows the lasting influence of this substance not only on immune cells (phagocytes, B cells, T cells with regulatory action), but also on the neurotransmitter NK kappa B, which promotes chronic inflammation and which, due to the above-mentioned events, is able to to switch on the so-called inflammation genes permanently. Based on personal experience and knowledge of the literature, a daily dose of 2-3,000 IU can be recommended.

The 2nd naturopathic measure must be: Deacidification, reduction of permeability and increase of lymph flow:

It has been histologically proven that a chronic inflammation develops in the affected tissue, which means that in addition to increased pressure, permeability disorders of the lymph vessels also occur. Chronic inflammation leads to local acidosis, so alkaline agents are also indicated! Bioflavonoids counteract permeability disorders well, so innovazym plus (with omega 3 fatty acids, dosage 7 tablets / day and advice on fasting) is particularly effective in combination with innova balance. Even a certain increase in lymph flow can also be achieved with proteases. Lymph drainage (attention, contraindications for existing tumors!) Leads to a clear stimulation of the lymph flow and must therefore be integrated into the overall therapy concept.

Experience has shown that many sufferers have a disorder of the intestinal flora due to the long-term illness and various attempts at therapy with antibiotics. For example, a 3 month cure with enterococci (Symbioflor1) or lactobacilli / bifidobacteria (Symbiovital), possibly with Mutaflor (E. coli strain), is recommended.

The findings and results cited here are based on empirical medicine, but due to the large number of therapeutic agents, they have not been examined in DB placebo-controlled studies in the sense of classical medicine. Can chronically suffering people be expected to wait for “clean clinical results” that are difficult to achieve anyway due to their complexity?

However: the parallel measure must beto permanently reduce the existing pressure. This is achieved through complex decongestive therapy.

The amount of fluid remaining in situ creates increasing pressure and dilates the lymphatic vessels. The normal structure of the lymphatic vessels intima, media with muscle layer and adventitia (outer layer) changes.

Since there is obviously an oxygen deficiency in the tissue, naturopathic therapists also use OZONE (ROCKITANSKY BOOTS) or intravenous oxygen therapy according to Dr. REGELSBERGER into consideration.

The guideline of classical medicine presents the pathophysiology / development of chronic LÖ similarly, but attaches little importance to medicinal measures, in particular the therapeutic measures presented here are not mentioned. This forces the patient, among other things, to bear the costs of these valuable measures himself.

However, it cannot be ruled out that the future will bring changes here: Even now (2011), bromelain or combinations and antioxidants are presented as meaningful and sustainable in the journal for complementary medicine.

Food should be adjusted in line with the overall biological situation and attention must be paid to the (chronically acting) stress! The effects of heat (sauna, sunbathing, etc.) on the lymphedema must be strictly avoided. Hypertensive drugs containing diuretics should not be taken by such patients, as they have no influence on the protein-rich edema!

Surgical therapy options:

There are currently some promising therapy methods - such as those used e.g. This can be practiced, for example, at the University of Freiburg in cooperation with the Foeldi Clinic or plastic-surgical departments at other universities in Erlangen or Heidelberg - but the possible procedures have not yet caught on in Germany. Those affected can find a good overview of the current options on the website of the “Association for the Promotion of Lymphedema Therapy”)

Prophylaxis is currently insufficient

Of course, it would be optimal to instruct the patient in advance (before the operation / treatment) about the possible development of a LÖ and to start the treatment immediately after the operation. The current situation is characterized by the fact that the majority of patients neither undergo rehabilitation after surgery nor are they informed about the therapeutic options. This is an oversight that should not be blamed on the doctors, but primarily on the health insurance companies.

Literature (selection)

Földi E et al .: For the diagnosis and therapy of lymphedema. Deutsches Ärzteblatt 95, 1998

GfbK INFO: Lymphedema. 2015

Inderst R. Chronic low-level inflammation. EHK 66, 2017

Korpan M: treatment of lymphedema with enzymes. MMW Taschenbuch, Ed .: Wrba H et al Munich 1997

Force K: lymphedema. MMW update Med. No. 16/2001

Negar Vaezipour:

Incidence and risk factors of secondary lymphedema after therapy for breast cancer

DISSERTATION Freiburg 2015


Siems W and R Brenke: Comprehensive treatment of chronic lymphedema. DAZ 38/2004

AWMF guideline: Diagnosis and therapy of lymphedema-2009


As additional information, As a link I already have the page ofhttp://www.biokrebs.de/and would like to present the Enzyme page today. http://www.biokrebs.de/therapien/immunsystem/enzyme

“Enzymes play a role in practically all metabolic processes in the body. In biological cancer therapy, they are among the active ingredients that help to normalize the immune system that has gotten out of hand:

  • They expose tumor cells so that they can be recognized by the immune system. They dissolve so-called immune complexes that irritate the immune system. Killer and phagocytes can thus direct their activity against tumor cells again.
  • They also inhibit inflammation and allow tissue swelling to subside.
  • Enzymes strengthen the immune system, improve wound healing and prevent edema and can alleviate side effects during chemotherapy or radiation therapy.

In supportive cancer therapy, primarily proteolytic, i.e. protein-splitting enzymes, are used. It is primarily bromelain from pineapple, papain from papaya, as well as trypsin and chymotrypsin from pancreas of animals. The preparations contain these enzymes in a highly purified form. There are purely vegetable (such as Wobenzym P, Bromelain POS, Regazym Plus, Proteozym) or mixed animal-vegetable (such as Phlogenzym, Enzym-Wied N, Neozym E, Wobe-Mucos NEM or KaRazym).

The time it takes to take the enzymes must be observed: this should take place 60 to 90 minutes before meals, as otherwise the functionality of the enzymes is not guaranteed. "

A few small excerpts from a very informative book by Ty Bollinger "Understanding cancer and healing it naturally" Kopp VerlagI would also like to share it with you today. Pages 369 - 370. I have recommended this book so often and also given it away, it is definitely worth buying !!!!

"Digestive enzymes"

Enzymes play the main role in digestion. There are three main categories of digestive enzymes:

Proteases (for protein digestion)

Amylases (digestion of carbohydrates)

Lipases (digestion of fats)

The proteases produced by the pancreas are often referred to as "proteolytic" (protein digesting) enzymes. From the age of 30, the body's own production of enzymes decreases drastically.


We know that edema is usually rich in protein, so it shouldn't be treated with diuretics. It then seems logical to me that enzymes help. I wish you all as much success as I have with it, of course not everyone will react positively to who you talk to about it, the views about food and supplements are very divided, sometimes I think that some "fear" that we are in our own wellbeing take the hand. I can only say that it is worth trying and that I am the best example of it.